(82) Timaeus: For seeing that there are four elements of which the body is compacted,—earth, fire, water and air,—when, contrary to nature, there occurs either an excess or a deficiency of these elements, or a transference thereof from their native region to an alien region; or again, seeing that fire and the rest have each more than one variety, every time that the body admits an inappropriate variety, then these and all similar occurrences bring about internal disorders and disease. For when any one element suffers a change of condition that is contrary to nature, all its particles that formerly were being cooled

(83) Timaeus: and all other such humors as pour forth in the daily purgings of the body. And all these are factors in disease, whenever the blood is not replenished naturally from meats and drinks but receives its mass from opposite substances contrary to Nature's laws. Now, when the flesh in any part is being decomposed by disease, but the bases thereof still remain firm, the force of the attack is reduced by half, for it still admits of easy recovery;

(84) Timaeus: as it crumbles, into its nutriment which then passes into flesh, and this flesh falling into, the blood causes all such maladies to be more violent than those previously described. And the most extreme case of all occurs whenever the substance of the marrow becomes diseased either from deficiency or from excess; for this results in the gravest of diseases and the most potent in causing death, inasmuch as the whole substance of the body, by the force of necessity, streams in the reverse direction. A third class of diseases takes place, as we must conceive, in three ways,

(82) Timaeus: Again, in the structures which are naturally secondary in order of construction, there is a second class of diseases to be noted by him who has a mind to take cognizance of them. For inasmuch as marrow and bone and flesh and sinew are compacted from the elements,—and blood also is formed from the same constituents, although in a different way,— most of the other maladies come about like those previously described, but the most severe of them have dangerous results for the reason following: whenever the production of these secondary substances proceeds in the reverse direction, then they are corrupted. For in the order of nature flesh and sinews arise from blood,

(114) Behold! Man becomes weak, faint and sick, and if no Remedy be used, then he soon falls into Death. The Sickness is caused either by some bitter and astringent Herb which grows out of the Earth, or else caused by an evil, mortiferous deadly Water, or by several Mixtures of earthly Herbs, or by some evil stinking and rank Flesh or Meats, and Surfeit from thence to Loathing;

(13) Of phenomena of this sphere some derive from the Kosmic Circuit and some not: we must take them singly and mark them off, assigning to each its origin.

The gist of the whole matter lies in the consideration that Soul governs this All by the plan contained in the Reason-Principle and plays in the All exactly the part of the particular principle which in every living-thing forms the members of the organism and adjusts them to the unity of which they are portions; the entire force of the Soul is represented in the All, but, in the parts, Soul is present only in proportion to the degree of essential reality held by each of such partial objects. Surrounding every separate entity there are other entities, whose approach will sometimes be hostile and sometimes helpful to the purpose of its nature; but to the All taken in its length and breadth each and every separate existent is an adjusted part, holding its own characteristic and yet contributing by its own native tendency to the entire life-history of the Universe.

The soulless parts of the All are merely instruments; all their action is effected, so to speak, under a compulsion from outside themselves.

The ensouled fall into two classes. The one kind has a motion of its own, but haphazard like that of horses between the shafts but before their driver sets the course; they are set right by the whip. In the Living-Being possessed of Reason, the nature-principle includes the driver; where the driver is intelligent, it takes in the main a straight path to a set end. But both classes are members of the All and co-operate towards the general purpose.

The greater and most valuable among them have an important operation over a wide range: their contribution towards the life of the whole consists in acting, not in being acted upon; others, but feebly equipped for action, are almost wholly passive; there is an intermediate order whose members contain within themselves a principle of productivity and activity and make themselves very effective in many spheres or ways and yet serve also by their passivity.

Thus the All stands as one all-complete Life, whose members, to the measure in which each contains within itself the Highest, effect all that is high and noble: and the entire scheme must be subordinate to its Dirigeant as an army to its general, "following upon Zeus"- it has been said- "as he proceeds towards the Intelligible Kind."

Secondary in the All are those of its parts which possess a less exalted nature just as in us the members rank lower than the Soul; and so all through, there is a general analogy between the things of the All and our own members- none of quite equal rank.

All living things, then- all in the heavens and all elsewhere- fall under the general Reason-Principle of the All- they have been made parts with a view to the whole: not one of these parts, however exalted, has power to effect any alteration of these Reason-Principles or of things shaped by them and to them; some modification one part may work upon another, whether for better or for worse; but there is no power that can wrest anything outside of its distinct nature.

The part effecting such a modification for the worse may act in several ways.

It may set up some weakness restricted to the material frame. Or it may carry the weakness through to the sympathetic Soul which by the medium of the material frame, become a power to debasement, has been delivered over, though never in its essence, to the inferior order of being. Or, in the case of a material frame ill-organized, it may check all such action upon the material frame as demands a certain collaboration in the part acted upon: thus a lyre may be so ill-strung as to be incapable of the melodic exactitude necessary to musical effect.

(86) Timaeus: and it produces diarrhoea and dysentery and all suchlike maladies. When a body has become diseased mainly from an excess of fire, it produces constant inflammations and fevers; when from air, quotidian fevers; when from water, tertian fevers, because that element is more sluggish than air or fire; and when from earth, which is the fourth and most sluggish of the elements and is purged in four-fold periods of time, it causes quartan fevers and is cured with difficulty.

(11) We have a common instance of this referring to second causes what ought to be referred to the First Cause in the case of so-called illness. For instance, if a man ceases to take any interest in worldly matters, conceives a distaste for common pleasures, and appears sunk in depression, the doctor will say, "This is a case of melancholy, and requires such and such a prescription." The physicist will say, "This is a dryness of the brain caused by hot weather and cannot be relieved till the air becomes moist." The astrologer will attribute it to some particular conjunction or opposition of planets. "Thus far their wisdom reaches," says the Koran. It does not occur to them that what has really happened is this: that the Almighty has a concern for the welfare of that man, and has therefore commanded His servants, the planets or the elements, to produce such a condition in him that he may turn away from the world to his Maker. The knowledge of this fact is a lustrous pearl from the ocean of inspirational knowledge, to which all other forms of knowledge are as islands in the sea.

(86) Timaeus: Such is the manner in which diseases of the body come about; and those of the soul which are due to the condition of the body arise in the following way. We must agree that folly is a disease of the soul ; and of folly there are two kinds, the one of which is madness, the other ignorance. Whatever affection a man suffers from, if it involves either of these conditions it must be termed “disease”; and we must maintain that pleasures and pains in excess are the greatest of the soul's diseases. For when a man is overjoyed or contrariwise suffering excessively

(84) Timaeus: countless diseases of a painful kind are produced, accompanied by much sweating. And often, when the flesh is disintegrated, air which is enclosed in the body and is unable to pass out brings about the same pangs as those caused by the air that enters from without; and these pangs are most severe when the air surrounds the sinews and the adjacent veins and by its swelling up strains backwards the tendons and the sinews attached to them; hence it is actually from this process of intense strain that these maladies have derived their names of “tetanus” and “opisthotonus.” Of these maladies the cure also is severe for what does most to relieve them is, in fact, an attack of fever.

(122) "Thou art of fire; return to thy root!" In the body there are seventy-and-two diseases; Disease comes to rend the body asunder, The four elements are as birds tied together by the feet; Death, sickness and disease loose their feet asunder. The moment their feet are loosed from the others, 'The bird of each element flies off by itself. The repulsion of each of these principles and causes That it may dissolve these composite bodies of ours, The bird of each part tries to fly away to its origin;

(21) He asked : “ To which of the four elements does thy sickness belong, earth, water, fire, or air ? ’ He replied : “ This sickness [of mine] does not belong to the earth element, nor is it separated from it; so with water, fire and air elements. But the sickness of all beings is caused by the four elements and as they are sick therefore am I sick.”

(89) Timaeus: apart from the accidents due to necessity. For from the very beginning the triangles of each creature are constructed with a capacity for lasting until a certain time, beyond which no one could ever continue to live. With respect to the structure of diseases also the same rule holds good: whenever anyone does violence thereto by drugging, in despite of the predestined period of time, diseases many and grave, in place of few and slight, are wont to occur. Wherefore one ought to control all such diseases, so far as

(8) What can this other cause be; one standing above those treated of; one that leaves nothing causeless, that preserves sequence and order in the Universe and yet allows ourselves some reality and leaves room for prediction and augury?

Soul: we must place at the crest of the world of beings, this other Principle, not merely the Soul of the Universe but, included in it, the Soul of the individual: this, no mean Principle, is needed to be the bond of union in the total of things, not, itself, a thing sprung like things from life-seeds, but a first-hand Cause, bodiless and therefore supreme over itself, free, beyond the reach of kosmic Cause: for, brought into body, it would not be unrestrictedly sovereign; it would hold rank in a series.

Now the environment into which this independent principle enters, when it comes to this midpoint, will be largely led by secondary causes : there will therefore be a compromise; the action of the Soul will be in part guided by this environment while in other matters it will be sovereign, leading the way where it will. The nobler Soul will have the greater power; the poorer Soul, the lesser. A soul which defers to the bodily temperament cannot escape desire and rage and is abject in poverty, overbearing in wealth, arbitrary in power. The soul of nobler nature holds good against its surroundings; it is more apt to change them than to be changed, so that often it improves the environment and, where it must make concession, at least keeps its innocence.